Page 80

The Krebs Cycle

1. Inhibition of the ETOP (Draw these on the pathway page)
   1. Methylene Blue

      
      
      

   2. DPIP

      
      
      

   3. Antimycin A

      
      
      

   4. Ascorbic Acid

      
      
      

   5. Oxygen analogs (e.g.: cyanide and azide)
      
      
      
      

2. THE KREBS CYCLE (aka: tricarboxylic acid cycle; citric acid cycle)
   1. Benefits of the cycle
      1. Maximum oxidation to yield maximum NADH to yield maximum ATP

      2. Easily disposed of end-product (no accumulation of toxicity)

      3. Intermediates may be used in other pathways (anabolism)

   2. The Cycle's Pathway (see page 256)

   3. P/O (write these on the pathway)

   4. Radioisotopic labelling and tracing (write these also on the pathway)
      We will be primarily concerned with radio-carbon (₁₄C)

   5. Important metabolic Intermediates (box these compounds on the pathway)

   6. Inhibitors