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The Fate of Pyruvate

There are three main alternatives for disposing of pyruvate

1. Alcohol Dehydrogenase (ADH)

   
   
   
   
   

2. Lactic Dehydrogenase (LDH)
   1. The Generalize Reaction
      
      
      
      

   2. The Physiological Reactions
      1. M4-LDH
         
         
         
         
         
         
         
         

         

      2. H4-LDH
         
         
         
         
         
         
         
         

         

      3. Serum Electrophoresis
         
         
         
         
         
         
         
         

   Pantothenic Acid (a portion of CoA) →

3. Korkes-Gusälus Pathway (see pages 60 and 252)

   Cofactors needed: thiamine pyrophosphate, lipoic acid and Co