Lecture 5: General Viral Anatomy and Consequences

1. General Viral Anatomy
   1. The Nucleocapsid
      1. Constituents
         1. Capsid > capsomers
         2. Peplos > peplomers
         3. Nuclear material

      2. Taxonomic considerations
         1. By morphology
         2. By nucleic acid type -
            

   2. Two examples
      1. Adenovirus V (gives people BAD sore throat)

      2. Coliphage Type-4 (T4)
         

   3. Methods for determining the construction of virions
      1. Normal electronmicroscopy

      2. Shadowed images in EM

      3. Three dimensional EM

2. Consequences
   1. Sensitivities to disruptive chemicals (e.g.: solvents)
      1. Lipid solvents

      2. Enzymes

   2. Movement through fluids
      1. Plaque morphology / Diffusion

      2. Sedimentation

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