Co-linearity of the sequences of the gene and its product.

Five Points of Genetic Expression - I
Co-linearity of the sequences of the gene and its product.
Class Day #6

The saboteur Analogy of Dr. Sol Spiegelman
1. Spiegelman, the person:
  1. Almost got Nobel Prize but published too late on reverse transcriptase.
  2. Spudnut Shop roundtable discussions on research.
  3. The problems of an RNA genome operating in a DNA dominated universe.
2. A saboteur gets GM to produce another company's products
Co-linearity of the code in a gene and its output protein.
(The first of five points of gene expression.)
1. Yanofsky (1967): trp mutants and gptrp
  1. Glimpse of circular genetic map of E. coli
  2. The trp operon
  3. Isolation of point mutants in one of the trp cistrons
  4. Proportions of "sense" to "non-sense" in the synthetase produced by these point mutants.
2. Min-Jou (1972): RNA virus's capsid.
  1. Differently placed mutations in the RNA caused sequentially damaged capsomers.
3. Fiers (1976): MS2-phage genome sequences (3569 bases)
  1. Sequenced the genome and the capsomer
  2. Produced point mutants in the RNA genome
  3. Sequenced capsomers of the mutants showed position correlation with mutation positions in the RNA